Loss of muscle protein, as a rule, the central

Weight loss often occurs in patients with chronic obstructive pulmonary disease (COPD), which negatively affect their quality of life, response to treatment and survival. Loss of muscle protein, as a rule, the central component of weight loss in patients with COPD. Attempts to bring the loss of muscle mass in patients with COPD, supplying a large amount of protein and calories that these patients have failed. Gains in muscle mass in COPD is difficult to achieve if specific metabolic sent. Scientists recently found that changes in the metabolism of proteins present in normal patients with COPD weight. Elevated levels what are the side effects of lasix of protein synthesis and breakdown rates were found in this group of COPD that changes are already present before there is a loss of muscle mass. In addition, decreased plasma essential amino acids (EAA) levels were observed in patients with COPD. This decrease in plasma EAA were significantly associated with the presence of muscle mass in patients with COPD. So far, limited research has been done studying protein metabolism and response to diet in patients with COPD. Previous studies support the concept of essential amino acids (EAA) as anabolic stimulus in young and elderly and in the states, insulin resistance. So far, no information is present on the anabolic effect of EAA in elderly patients with COPD. Therefore, our assumption that high-leucine essential amino acid mixture specifically designed to stimulate protein anabolism will be sent to the metabolic changes in patients with COPD. In this study, the effect of acute EAA supplement food for the whole body, muscle and liver protein metabolism will be considered in patients with COPD and compared with the addition that includes a balanced mixture of amino acids. Primary endpoints will be the degree of stimulation of protein synthesis the whole body, as this is the main mechanism by which any amino acid or protein results in muscle anabolism and decrease endogenous protein breakdown. Both endpoints will be measured by isotope methodology, which is considered the reference method. .